USA — Pfizer Inc is set to invest more than US$2.5 billion at its drug-making plants in Belgium and Ireland, gearing up to launch new products it hopes can replace lost revenue as patents expire and COVID-19 vaccine sales decline, news agency Reuters reports.

The drugmaker said last week it plans to spend more than 1.2 billion euros (US$1.26 billion) to expand its Puurs, Belgium manufacturing site, matching the investment at its Dublin, Ireland plant announced recently.

The Puurs site has played a key role in the production of COVID-19 vaccine shots Pfizer developed with its German partner BioNTech using the messenger RNA (mRNA) technology.

Output started there in late 2020 when Europe and the US began rolling out shots to tackle the pandemic.

It is all aligned with the growth of our pipeline,” Mike McDermott, Chief Global Supply Officer, Pfizer, told Reuters.

If you project out the capacity modeling for these two sites … you’ll find a gap in our ability to serve that (growth). So, this is proactive investment,” he said.

Pfizer’s revenue is expected to top US$100 billion this year – more than double its pre-pandemic level – on the strength of sales of its COVID-19 vaccine and treatment, Paxlovid.

However, COVID-related sales are expected to drop sharply over the next few years, and Pfizer also faces the loss of patent protections for some big-selling medicines after 2025, such as cancer treatment Ibrance and arthritis drug Xeljanz.

The sizeable investment and creation of jobs in Europe come at a critical time for the region as companies struggle with soaring costs of energy, labor, raw materials, and credit, fueling worries over a recession.

The crisis has hit energy-intensive industries, such as fertilizers and chemicals, particularly hard, prompting some to shift manufacturing to locations where cheap energy is abundant, such as the US.

Drug manufacturers have also warned that energy costs risk undermining the recent push to boost generic medicines production in Europe to make the region more self-sufficient.

Pfizer hopes to introduce as many as 19 new medicines over the next year and a half, including treatments for ulcerative colitis and migraines, as well as its vaccine for Respiratory Syncytial Virus (RSV).

Our portfolio is strong and requires an expansion of our network to accommodate these new products that will really make an impact,” McDermott said.

The new products produced at the plants will cover various therapeutic areas including rare diseases, inflammation, and immunology, he said.

The expansion in Ireland will add around 400 to 500 jobs and allow it to double the amount of drug substance it makes at the site, which produces material for complex biologic drugs and vaccines.

In Belgium, Pfizer is expanding the Puurs site’s capacity to finalize and bottle doses of drug substance. It is also expanding its packaging and cold storage capabilities there.

The new projects will result in an additional 250 jobs at the Belgian plant, whose workforce has grown to 4,500 people from 2,800 before the pandemic.

Pfizer has also been spending significantly to expand its manufacturing capacity in the US. The New York-based drugmaker has announced plans to expand its Kalamazoo, Michigan, Rocky Mount, North Carolina, and McPherson, Kansas plants.

It has also said it will spend close to US$1 billion to boost its ability to produce gene therapies at sites in Massachusetts and North Carolina.

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