The Phase Ib/II trial will assess safety, tolerability, and early signs of clinical activity. Researchers will combine Boehringer Ingelheim’s investigational T-cell engager, obrixtamig, with Zai Lab’s antibody-drug conjugate (ADC), zocilurtatug pelitecan (zoci).
Through this agreement, Gilead now controls global rights to KT-200, an oral CDK2 molecular glue degrader designed to treat cancer.
The collaboration centers on developing targeted radiopharmaceuticals that leverage Regeneron’s antibody portfolio and VelocImmune mice technology.
C4 Therapeutics will use its proprietary TORPEDO platform to design the degrader payloads, while Roche will oversee antibody selection, conjugation chemistry, preclinical testing, and clinical development
Histotripsy uses precisely focused ultrasound energy to destroy tumours from outside the body, eliminating the need for surgery, radiotherapy, or chemotherapy.
The two companies began collaborating in 2024 through an option and license agreement valued at up to USD 465 million, which granted Gilead access to Tubulis’ proprietary ADC platforms.
The work centres on magnetic resonance imaging (MRI), a widely used diagnostic tool that allows doctors to visualise tumours inside the body.
The recall covers all batches of Urografin 60% manufactured between October 2020 and March 2025.
The drug targets a specific immune deficit associated with bladder cancer, offering a mechanism distinct from conventional treatments.
The alert followed official communication from Roche Nigeria after the pharmaceutical company received multiple complaints from healthcare professionals nationwide.