Merck plans to present the BRUNELLO results at the American Academy of Ophthalmology Annual Meeting in New Orleans on October 10 and discuss the findings with regulatory authorities.
The withdrawal changes the immediate US regulatory path for the ES-SCLC indication, but the ongoing Phase III programme provides the companies with another source of clinical data.
Lung adenocarcinoma is the most common form of lung cancer and can occur in both smokers and people who have never smoked.
Over the past five years, the program has expanded its molecular diagnostic capabilities and introduced expedited genomic oncology profiling to provide oncologists with timely information when treatment decisions are urgent.
TAVI is widely used to treat severe aortic stenosis, a condition in which narrowing of the aortic valve restricts blood flow from the heart.
The researchers focused on polygenic risk scores, which combine the effects of multiple genetic variants to estimate a person’s inherited susceptibility to a disease. However, existing methods may overlook genetic information associated with disease risk.
Researchers will need about 55,000 participants to support currently active studies.
Researchers from Tohoku University launched the study in 1986 under Professor Yutaka Imai in response to the high burden of hypertension and stroke in Ohasama, Iwate Prefecture.
The study will generate data that researchers can use to improve disease prediction, early detection, and prevention while supporting the development of more personalized healthcare.
The rollout follows the drug’s approval in China in June 2026 and marks the start of its wider clinical use for people requiring urgent post-exposure protection against rabies.